Center for Thyroid, Parathyroid, and Adrenal Disease

7/2011 – Present
Phase III trial of E7080 in 131I-refractory differentiated thyroid cancer. In collaboration with Eisai Inc. E7080-G000-303 is a multicenter, randomized, double-blind, placebo-controlled study that compares progression-free survival of subjects with 131 I-refractory differentiated thyroid cancer (DTC) treated with E7080 versus placebo.’
Principal Investigator: Alexander Shifrin, M.D.
Sub-investigators: Sunil. Asnani M.D., Danielle Lann, M.D.

05/2010 – Present
Retrospective study of the expression of the Tyrosine Kinase Receptor C-Kit, Proliferation Antigen Ki-67, and Tumor Suppressor P53 in differentiated types of thyroid cancer.
Principal Investigator: Alexander Shifrin, M.D.
Sub-Investigators: T. Matulewicz, M.D., Arthur Topilow, M.D., Department of Surgery, Oncology, Pathology, Jersey Shore University Medical Center

01/2010 – Present
Preoperative ultrasonagraphy in primary hyperparathyroidism is more accurate and valuable when performed by an endocrine surgeon.
Principal Investigator: Alexander Shifrin, M.D.
Sub-Investigators: Sunil Asnani, M.D., Jerome Vernick, M.D. Department of Surgery and Endocrinology, Jersey Shore University Medical Center

09/08/2010– Present
Comparison of local and general anesthesia for thyroid surgery.
Principal Investigator: Alexander Shifrin, M.D., Department of Surgery and Anesthesiology, Jersey Shore University Medical Center

07/2009 – Present
Molecular profiling of indeterminate thyroid nodule fine needle aspirates to determine patterns predictive of benign or malignant disease. Sponsored by Veracyte, Inc 7000 Shoreline Court, Ste 250, South San Francisco, CA 9480.
Principal Investigators: Erik Alexander, M.D., and Bryan Haugen, M.D., Alexander Shifrin, M.D.

11/2008.
Role of RET proto-oncogene mutation in the development of simultaneous – present medullary and papillary thyroid carcinomas in 107 members of the family with the RET V804M proto-oncogene mutation.
Principal Investigator: Alexander Shifrin, M.D.